The project identified thermostable hydrolases enzymes from hot terrestrial environments, using metagenomic screening methods, aided by novel bioinformatic tools developed to facilitate function prediction of genes from metagenomes that show low or no sequence homology to enzymes of known function that can contribute to efficient industrial processes. A range of high-throughput screening technologies were developed and employed to identify novel hydrolases.
Partners included: University of Copenhagen, Novozymes A/S (Denmark); Wageningen Universiteit, MicroDish BV (Netherlands); Montana State University (USA); Stiftelsen Norges Geotekniske Institutt (Norway); Winogradsky Institute of Microbiology (Russia); University of Exeter (UK); Sigma-Aldrich Production GmbH (Switzerland); Consiglio Nazionale delle Ricerche (Italy); National Technical University of Athens (Greece); Essen (Germany). Project Site>